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VIP-Cre (stock No. 010908), SST-Cre (stock No. 013044), and C57B/L6 mice were from Jackson Lab. Experiments were performed on adult (age 3–6 months) mice of both sexes. Nevertheless, characterization of the Aap needs to be followed using gene inactivation and cell wall localization. To investigate the functional role of the α5-Gabaar subunit at VIP+ inputs, we applied a chemogenetic approach allowing selective silencing of Vipcre interneurons by CA1 injection of AAV encoding a Cre-dependent Gi-coupled designer receptor… Cognitive performance in people varies according to time-of-day, with memory retrieval declining in the late afternoon-early evening. However, functional roles of local brain circadian clocks in memory performance remains unclear.
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